Insulin Receptors are areas on the outer part of a cell that allow the cell to join or bind with insulin that is in the blood.
When the cell and insulin bind together, the cell can take glucose (sugar) from the blood and use it for energy.
The main activity of activation of the insulin receptor is inducing glucose uptake.
For this reason "insulin insensitivity", or a decrease in insulin receptor signaling, leads to diabetes mellitus type 2 - the cells are unable to take up glucose, and the result is hyperglycemia (an increase in circulating glucose), and all the sequelae which result from diabetes.
Diabetic Coma
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